When most people think about semaglutide, they think of the injectable forms. However, there are also semaglutide tablets. The semaglutide tablet, known as Rybelsus, is a convenient option for aiding in weight loss, managing type 2 diabetes, and possibly reducing the risk of heart issues. Those who aren’t fans of using injections might prefer to try oral medicines like this one.
In this article, we’ll discuss how these oral tablets work, their potential benefits, and side effects, and how they compare to injectable forms. We’ll also provide tips on proper use and storage. So, without further adieu, let’s talk about Rybelsus (semaglutide)!
What is Rybelsus (Semaglutide)?
Semaglutide is an active ingredient found in medications such as Ozempic, Wegovy, and Rybelsus. It is classified as a glucagon-like peptide-1 (GLP-1) receptor agonist, which is vital for controlling blood sugar levels in type 2 diabetes. Beyond diabetes management, semaglutide also assists in weight management and reduces the risk of heart attack or stroke.
In its oral tablet form, semaglutide is sold under the brand name Rybelsus. This approach provides a convenient alternative for those who would find doing a subcutaneous injection challenging. In addition, a semaglutide injection, like Ozempic or Wegovy, might not be available, as there’s often a shortage.
How Does Rybelsus (Semaglutide) Work?
Semaglutide activates receptors in the body that regulate blood sugar levels. When blood glucose levels increase, semaglutide increases insulin levels from the pancreas, lowering these levels.
Additionally, semaglutide suppresses glucagon secretion from pancreatic cells, further aiding in reducing blood sugar levels. It also delays gastric emptying, reducing appetite and promoting more stable blood sugar levels.
Rybelsus (Semaglutide) FDA Approved Use
Like Ozempic, Rybelsus semaglutide is also FDA-approved to improve blood sugar levels in those with type 2 diabetes. In addition, it’s meant to be used alongside diet and exercise.
Although it’s not currently approved by the FDA to help people lose weight, losing weight is still a side effect of the medication. As a result, a health care provider may prescribe it for off-label use.
Does Rybelsus (Semaglutide) Help People Lose Weight?
Clinical trials suggests that this medication is effective for reducing weight. Novo Nordisk, which is the manufacturer of Rybelsus (semaglutide), conducted a 68-week clinical trial. They noted significant weight reduction in participants when the medication was taken in high doses. In fact, they lost over 17% of their initial body weight when taking a 50 mg dose of the drug.
Another study evaluated participants taking the highest standard dose, which is 14 mg dose. Those individuals lost less than 5% of their total weight over 52 weeks, so the dose makes a difference.
Semaglutide Tablets vs Semaglutide Subcutaneous Injection
Patients can choose between two main forms of semaglutide: oral tablets and injections. Rybelsus, the oral form, eliminates the need for needles, making it appealing to those who prefer medications taken by mouth. In contrast, Ozempic and Wegovy are subcutaneous injections, which may be less convenient for some.
Choosing between semaglutide tablets and injections depends on personal preference and medical advice. Semaglutide injections offer a steady and potentially more controlled release but require handling needles and proper injection techniques. In addition, it might be a better option for those who have trouble swallowing.
Oral semaglutide integrates easily into daily routines but must be taken exactly as directed for effectiveness.
Ultimately, while they come in different dosage forms, they work similarly.
Proper Usage of Rybelsus (Semaglutide)
Proper usage is crucial for the effective functioning of Rybelsus (semaglutide). These tablets must be taken on an empty stomach first thing in the morning and with only plain water. This ensures correct absorption and effective management.
Dosage Instructions
Adults starting semaglutide tablets are typically prescribed 3 milligrams (mg) daily for 30 days. This dosage is solely meant to initiate treatment, but it’s not said to be effective enough to achieve glycemic control. A lower dose allows you and your medical provider to see how your body tolerates the drug.
It’s suggested that individuals take the tablet immediately after waking up, at least 30 minutes before any food, beverage, or other oral medications. Available in 3 mg, 7 mg, and 14 mg dose, the dosage can be adjusted based on individual needs.
Do not change the dosage unless directed by a healthcare provider. Swallow the tablets whole with plain water at least 30 minutes before any food, drink, or other medicines. This routine maximizes absorption and effectiveness.
Timing with Meals
Timing is crucial when taking semaglutide. For optimal results, take the tablet at least 30 minutes before the first meal, beverage, or medication of the day. This ensures proper absorption and effectiveness.
You’ll want to avoid eating or drinking anything except water before taking semaglutide. Be sure to swallow the tablet whole as it’s not meant to be split, crushed, or chewed. Following these guidelines helps maximize semaglutide’s benefits and maintain better blood sugar control.
Missed Dose Guidelines
Not sure how to make up for a missed dose? We suggest that you skip the missed dose and take the next dose the following day as you don’t want to take an extra dose. Still unsure? Reach out to your healthcare provider and they’ll be able to guide you.
Benefits of Semaglutide Oral Tablets
Semaglutide oral tablets offer benefits beyond just lowering high blod sugar. They enhance insulin release and lower glucagon levels, maintaining stable blood sugar levels. Semaglutide also delays gastric emptying, reducing appetite and aiding potential weight loss.
Moreover, semaglutide has shown potential in reducing cardiovascular disease risk in diabetic patients. This makes it valuable for managing diabetes and improving heart health (e.g. high blood pressure).
Weight Management
As mentioned before, Rybelsus (semaglutide) leads to significant weight reduction, benefiting individuals with obesity or overweight.
This weight loss is due to reduced appetite and delayed gastric emptying, leading to fewer calories consumed and greater weight loss over time. Despite lacking FDA approval for this purpose, clinical study results are promising.
Beyond weight loss, semaglutide offers improved cardiovascular health and better disease management, making it a comprehensive solution.
Blood Sugar Control
Semaglutide effectively maintains stable blood glucose levels, especially when combined with a healthy diet and exercise. Designed to be used with dietary changes and physical activity, this medication ensures optimal effectiveness.
By effectively lowering blood glucose levels, semaglutide helps in managing and maintaining healthy blood sugar levels, which is crucial for diabetic patients. After all, high blood sugar can cause undesirable symptoms, like dry mouth, dry skin, drowsiness, and more. Incorporating lifestyle modifications enhances the medication’s benefits and leads to better disease control.
Cardiovascular Health
Semaglutide is associated with improved cardiovascular outcomes in individuals with type 2 diabetes. Studies have shown that it can lower the occurrence of major adverse cardiovascular events in individuals with obesity and heart disease, independent of blood sugar levels. This means that semaglutide not only helps in managing those with high blood sugar but also plays a crucial role in enhancing heart health.
One study actually found that those taking semaglutide had a clinically significant reduction in blood pressure following treatment.
Common Side Effects of Semaglutide Oral Tablets
Semaglutide oral tablets may present some side effects, just like other medications. Common side effects include gastrointestinal adverse reactions, like nausea, vomiting, and abdominal pain. Other effects may involve diarrhea and low blood sugar. Nausea and vomiting are particularly common and can be linked to stomach pressure or pain.
Symptoms of low blood sugar, such as shakiness, dizziness, and blurred vision, need careful monitoring. A healthcare provider may suggest glucose tablets or fruit juice if you’re experiencing such symptoms.
Stomach pain, often manifesting as bloating or gas, is more likely in individuals with existing gastrointestinal issues. Adjustments and consultation with a healthcare provider can help manage these side effects.
For the best outcome, be sure to report any side effects from Rybelsus (semaglutide) to your healthcare provider.
Serious Side Effects and Warnings
Serious side effects and warnings must not be ignored, even if common side effects are manageable. Regular check-ups, blood and urine tests, and reporting any lumps, changes to vision (e.g. blurred vision can be a sign of diabetic retinopathy), dehydration (e.g. check for dark yellow urine and dry mouth), gallbladder problems, and more are essential precautions.
An overdose can lead to severe nausea, vomiting, difficulty breathing, and dangerously low blood sugar levels. Signs of the latter include a fast heartbeat, kidney injury, dizziness, and more.
Serious Allergic Reactions
A life-threatening allergic reaction to Rybelsus (semaglutide) may manifest as anaphylaxis or angioedema, requiring urgent medical care. Symptoms include hives, trouble breathing, and swelling of the face or throat. Immediate medical attention is necessary if these symptoms occur.
Prompt recognition and response to serious allergic reactions are crucial. Be vigilant for any signs of an allergic reaction, as these require urgent medical help.
Thyroid Cancer and Tumor Risk
Patients should be aware of the increased risk of developing thyroid cancer and thyroid tumors when using Rybelsus (semaglutide). Though the risk of thyroid cancer or tumors is low, monitoring for any neck lumps or trouble swallowing is still important. Individuals with a history of medullary thyroid carcinoma or certain hereditary conditions should avoid using semaglutide.
Any indications of a thyroid tumor should prompt immediate consultation with a healthcare provider. Vigilance and early detection are key to managing potential risks.
Kidney Problems and Pancreatitis
Users should be aware of the risks of pancreatitis and kidney issues posed by Rybelsus (semaglutide). Symptoms of pancreatitis include severe stomach pain, chills, nausea, and vomiting. Report any symptoms related to pancreatitis to a healthcare provider promptly.
Monitoring for kidney problems and kidney disease, such as bloody urine, decreased urine output, and rapid weight gain, is equally important. If these symptoms occur, immediate medical attention is necessary to prevent severe complications.
Gallbladder problems
Some individuals report gallbladder problems, such as cholecystitis and cholelithiasis, while taking Rybelsus. Symptoms may include yellowing of the skin or eyes (e.g. jaundice), fever, severe pain in the upper stomach, and clay-colored stool.
Interactions with Other Medications
Rybelsus (semaglutide) may interact with other oral medications because it delays gastric emptying, so absorption may be impacted.
You should let your doctor know about any over the counter medicines and prescription drugs you’re taking so they can determine if there may be an interaction. They may suggest that you don’t take other oral medicines or other medicines at the same time you take Rybelsus, to avoid absorption issues.
It’s also suggested that healthcare providers consider reducing the dose of certain medications, like an Insulin Secretagogue or Insulin, at the same time. Doing so reduces the risk of hypoglycemia (low blood sugar).
Alcohol and food interactions can increase the risk of symptoms of low blood sugar and gastrointestinal adverse events also.
How To Store Semaglutide Oral Tablets
Proper storage of semaglutide oral tablets is essential to maintain their effectiveness. These tablets should be stored at room temperature, away from heat, moisture, and direct light. It’s important to keep them in their original bottle to protect them from moisture.
Always inspect the tablets before use for any signs of discoloration or unusual appearance, as these could indicate that the medication is not safe to use.
Additionally, keep semaglutide out of reach of children to prevent accidental ingestion.
Special Considerations
Certain conditions necessitate special considerations when using semaglutide. Regular medical evaluations are crucial to monitor for any serious side effects and ensure the medication is working effectively. Patients should have blood and urine tests done regularly and report any unusual symptoms to their healthcare provider immediately.
Rybelsus (semaglutide) is not recommended for individuals with multiple endocrine neoplasia type 2. It should also be avoided by those with a personal or family history of medullary thyroid cancer. Acute kidney injury is a potential risk, and immediate medical attention is required if symptoms like bloody urine or decreased urine output occur.
Lastly, medical professionals don’t advise that individuals take semaglatuide while pregnant or breastfeeding. It could cause potential risks to them and their unborn baby, so discuss with your doctor what’s best.
Contact Custom Health Centers About Semaglutide Tablets
Semaglutide oral tablets, such as Rybelsus, offer a versatile and effective option for managing type 2 diabetes and weight mangement.
If you’d like to learn more about Rybelsus (semaglutide), contact Custom Health Centers today! You’ll be able to speak with a healthcare provider to learn more about Rybelsus and other medications that may be a better for your needs.
We look forward to helping you along your health and fitness journey!
Frequently Asked Questions
What is the primary purpose of semaglutide oral tablets?
The primary purpose of semaglutide oral tablets is to manage type 2 diabetes by controlling blood sugar levels. Additionally, they assist in weight loss and may lower the risk of heart-related complications when combined with diet and exercise.
How should semaglutide oral tablets be taken?
Semaglutide oral tablets must be taken on an empty stomach, at least 30 minutes before the first meal, beverage, or medication of the day. It is important to swallow the tablets whole with water, avoiding any alteration such as splitting, crushing, or chewing.
What are the common side effects of semaglutide oral tablets?
Common side effects of semaglutide oral tablets include nausea, vomiting, diarrhea, symptoms of low blood sugar, and stomach pain, which may necessitate medical attention if severe. It is important to monitor these symptoms closely.
What should I do if I miss a dose of semaglutide?
If you miss a dose of semaglutide, simply skip the missed dose and continue with your regular dosing schedule without taking an extra dose. Always adhere to your doctor’s specific instructions for any dosing errors.
Are there any serious risks associated with semaglutide?
Yes, semaglutide poses serious risks, such as severe allergic reactions, an increased risk of thyroid tumors, pancreatitis, issues with vision, dehydration and more. It is essential to undergo regular medical evaluations and seek immediate attention for any unusual symptoms. If you have trouble breathing, please call 911.
